Endocrine Abstracts

Introduction: Cushing’s disease (CD) is an uncommon condition of excess endogenous glucocorticoids caused by ACTH secreting pituitary corticotroph adenoma. The purpose of this study is to review therapeutic outcomes and comorbidity of patients with CD in a single centre.Methods: We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014. (27 female and six male, median age 38 years...

The aim of this study was to investigate the expression of histological markers Ki-67, p53 and mitotic activity in pituitary adenomas and their correlation with the frequency of recurrence and progression of residual adenoma. The study comprised 94 patients treated at the Department of Endocrinology, University Hospital Center Zagreb in the period from 2005 to 2011. After the operation, 63.8% of patients had residual adenoma. In the minority of patients (12/60 patients, 20%) w...